Helping The others Realize The Advantages Of ceesdekker
Helping The others Realize The Advantages Of ceesdekker
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the framework and dynamics of chromosomes. Our study pursuits include things like:
Our team reports bacterial cell division and is aiming to represent a ‘bottom up biology’ in synthetic cells which can autonomously divide. Our most important fascination lies in cell division, chromatin composition, and spatial Management.
[Laughs] ‘It had been absolutely a terrific chance! At time, I was well aware that it could go wrong Which I could develop into a lot less productive, but I just dismissed that. Curiosity has usually been my strongest driving drive. And fortunately all of it worked out.’
Because 2000, Dekker has shifted the most crucial concentrate of his operate to biophysics in which he scientific tests the Homes of one biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was pushed by his fascination for the exceptional operating of Organic molecular buildings, as well as from the prolonged-expression standpoint that numerous fascinating discoveries could be predicted With this subject.[five] Present-day strains of research in his biophysics group are in the areas of:[6]
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Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
What distinguishes biology from chemistry is the fact that these factors with each other make up a dwelling method. The trick of stated lifetime, I believe, lies from the interactions, the interplay of People molecules. The massive issue about ceesdekker.net the origin of daily life remains unanswered. How did we ever evolve from easy molecules in the very intricate systems we see right now? We do not know. I need to work on These types of significant, open inquiries.’
2011, initially in vitro measurements of transportation across just one biomimetic nuclear pore complicated; advancement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
‘Yes, I recognize people had been astonished at the time. At the end of the nineties, After i was in my forties, I was Professor of Molecular Electronics and I have to confess that it experienced become a bit bored, I didn’t study A lot any more. The sphere went more into the appliance aspect, how you could potentially integrate nanotubes into electronic circuits.
Presently, we also understood that it ought to be attainable to work with one semiconducting carbon nanotube to generate a transistor — and we set out to make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and utilised the underlying silicon substrate as being a gate electrode, establishing The essential 3-terminal layout of a industry-influence transistor (Fig.
Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
1999, very first measurement of the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof to get a new Luttinger description of interacting electrons in nanotubes
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
Stable-point out nanopores have demonstrated to generally be a shockingly multipurpose probe for one-molecule Investigation of DNA. I'll describe a few of our latest findings – particularly DNA knots – in addition to our attempts to increase the capabilities of solid-point out nanopores even further more, from the course of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.