ceesdekker Can Be Fun For Anyone

ceesdekker Can Be Fun For Anyone

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Using one-molecule optical and AFM imaging and power-spectroscopy methods, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study interests involve:

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‘It was simply just a subject of selecting up a e-book on cell biology and beginning to go through. I had originate from a entire world of ultra-superior vacuums, cryostats and quantum phenomena, and now I used to be Operating at room temperature with molecular biology kits.

Non-equilibrium folding of particular person DNA molecules recaptured nearly a thousand periods in a very stable condition nanopore

This yielded a breakthrough. In just only a few months, we were being capable to evaluate transportation by means of somebody single-walled carbon nanotube. Dependant on minimal-temperature experiments by a superb PhD college student in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how with the Energetic study lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were being real quantum wires with incredibly lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.

Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes

What distinguishes biology from chemistry is always that these components jointly make up a living technique. The secret of explained life, I feel, lies in the interactions, the interplay of Those people molecules. The big problem with regards to the origin of lifestyle remains to be unanswered. How did we at any time evolve from straightforward molecules in the very intricate units we see right now? We do not know. I need to work on these kinds of major, open up concerns.’

Finding out DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.

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There was one issue even though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers had been truly not these kinds of wonderful conductors, which was ceesdekker somewhat disappointing. We Consequently broadened our perspective to test to uncover extra promising molecules.

FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division

2006, first demonstration of molecular sorting inside a lab on the chip making use of biomotors; discovery of nanobubbles in reliable-condition nanopores; and initially estimate of electrokinetic Electrical power conversion in a nanofluidic channel

Visualization of unstained DNA nanostructures with Innovative in-concentration transmission electron microscopy approaches

Solid-state nanopores have proven to be a amazingly multipurpose probe for one-molecule Investigation of DNA. I'll explain a number of our latest results – especially DNA knots – along with our efforts to broaden the abilities of good-point out nanopores even even more, while in the route of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.